photo credit: Amanda Lee

The Geropathology Research Network will be holding its 4th Geropathology Grading Committee Workshop on April 16th and 17th, 2018, at the University of Washington, Seattle, Washington.

This will be a working committee meeting dedicated to hands-on scope slide reading. The focus will be on the evaluation and comparison of lesion grades in specific organs and tissues from mice at various ages and drug testing regimens.


Contemporary Concepts in Toxicology (CCT) meeting

Dr. Warren Ladiges, the Director of the Geropathology Reseach Network, will be speaking at an upcoming satellite meeting entitled “Toxicological Concerns in Older Adults, a Neglected Majority” that will be held on March 10, 2018, at the Henry B. González Convention Center, San Antonio, Texas, immediately before the Society of Toxicology (SOT) 2018 Annual Meeting.

Older adults have uniquely increased susceptibilities to pharmaceuticals and environmental toxicants. Although considerable effort has been spent addressing the biological aspects of aging, including genetics and pharmacology, toxicological effects specific to older populations have been understudied. The primary goal of this forum is to increase understanding of the changes associated with the aging process and discuss ways in which these changes may influence toxicity outcomes. The discussions will have potential impact on the development of toxicological assessments, the drug development process, and clinical practice.

Further details about this meeting may be found in the meeting website: www.toxicology.org/events/shm/cct/ToxConcerns.asp.


Photo credit:  John Morton

On October 26th and 27th , 2017, the Geropathology Grading Committee held a workshop which succeeded with its objective of updating guidelines for the Geropathology Grading Platform (GGP) by adding several new tissues, refining scoring ranges, and developing additional descriptions to match specific lesion grades. A summary of the 3rd Geropathology Grading Committee Workshop can be found here.


Photo credit: Kateryna Tonyuk

The Geropathology Research Network will be holding its 3rd Geropathology Grading Committee Workshop on October 26th and 27th, 2017, at the University of Washington, Seattle, Washington.

This will be a working committee meeting dedicated to hands-on scope slide reading. The focus will be on the evaluation and comparison of lesion grades in specific organs and tissues from mice at various ages and drug testing regimens.


Geropathology Workshop at the IAGG World Congress.

The Geropathology Research Network will be hosting a Geropathology Workshop in conjunction with the 2017 IAGG World Congress. Please see the workshop agenda below:

GEROPATHOLOGY Workshop
Theme- Integrating Geropathology into Geroscience Projects

July 24th, 2017, 6-8 PM
Marriot Marquis, Sierra Conference Room
San Francisco, CA

Format– Informal roundtable discussion. A large laptop computer will be available for presenting a few ppt slides to a small group, but there will be no other audiovisual tools. Food and beverages will be provided.

INTRODUCTION

Geropathology background and current status- W Ladiges

NIA Geroscience overview- F Sierra

DISCUSSION ITEMS

  • Interpreting Geropathology lesion grades in mice
    • T Snider
    • D Imai
  • Geropathology Applications in Geroscience preclinical studies
    • L Neidernhofer
    • A Richardson
    • P Robbins
    • S Austad
    • R Buffenstein (or representative)
  • Moving Geropathology forward
    • Geropathology Grading Committee
    • Funding
    • Training and recruiting
    • Interactive website
    • Atlas

WRAP UP

Next workshop- Fall 2017 in Seattle, 2-day slide reading workshop


The Gerontological Society of America (GSA) will be hosting the World Congress of Gerontology and Geriatrics, where they will welcome the global community of aging scholars. GSA will be hosting this event in San Francisco from July 23rd to the 27th on behalf of the International Association of Gerontology and Geriatrics (IAGG). The GSA Annual Scientific Meeting, normally held each November, will not take place this year. However, the GSA will be implementing many of the Society’s traditional meeting activities in a modified fashion during the World Congress. For more details please visit www.iagg2017.org.


The Geropathology Grading Committee has published its first description of the Geropathology Grading Platform in the Journals of Gerontology: Biological Sciences.

A New Preclinical Paradigm for Testing Anti-Aging Therapeutics

Warren Ladiges, Jessica M. Snyder, Erby Wilkinson, Denise M. Imai, Tim Snider, Xuan Ge, Marcia Ciol, Christina Pettan-Brewer, Smitha P. S. Pillai, John Morton, Ellen Quarles, Peter Rabinovitch, Laura Niedernhofer, and Denny Liggitt

Abstract

Testing drugs for anti-aging effects has historically been conducted in mouse life-span studies, but are costly and time consuming, and more importantly, difficult to recapitulate in humans. In addition, life-span studies in mice are not well suited to testing drug combinations that target multiple factors involved in aging. Additional paradigms for testing therapeutics aimed at slowing aging are needed. A new paradigm, designated as the Geropathology Grading Platform (GGP), is based on a standardized set of guidelines developed to detect the presence or absence of low-impact histopathological lesions and to determine the level of severity of high-impact lesions in organs from aged mice. The GGP generates a numerical score for each age-related lesion in an organ, summed for total lesions, and averaged over multiple mice to obtain a composite lesion score (CLS). Preliminary studies show that the platform generates CLSs that increase with the age of mice in an organ-dependent !
manner. The CLSs are sensitive enough to detect changes elicited by interventions that extend mouse life span, and thus help validate the GGP as a novel tool to measure biological aging. While currently optimized for mice, the GGP could be adapted to any preclinical animal model.

To read the full text, visit the Journal of Gerontology: Biological Sciences



Credit: John Morton

On January 23rd and 24th, 2017, the Geropathology Grading Committee held a workshop which succeeded with its main goal of upgrading and expanding its Geropathology Grading Platform by evaluating and comparing lesion grades in specific organs and tissues from mice at various ages and drug testing regimes. A summary of the 2017 Geropathology Grading Committee Workshop can be found here.


Credit: Kateryna Tonyuk

The Geropathology Research Network will be holding its 2nd Geropathology Grading Committee Workshop on January 23rd and 24th, 2017, at the University of Washington, Seattle, Washington.

This will be a working committee meeting dedicated to hands-on scope slide reading. The focus will be upgrading and expanding our Geropathology Grading Platform.


The 2016 Gerontological Society of America (GSA) Annual Scientific Meeting will be held in New Orleans, Louisiana, November 16 – 20, 2016.


news_seattle

Credit: Carol Chan

The Geropathology Research Network will be holding a workshop in conjunction with the 45th Annual Conference of the American Aging Association and the Nathan Shock Center Summit on Personalized Geroscience.  

Location:   Bell Harbor International Conference Center,  Cove Conference Room, 2211 Alsakan Way, Seattle, WA 98121

Date & Time:   June 1st, 2016, 8:30 a.m. to 12:45 p.m.

For more details, please see the workshop agenda.